Diloxanide furoate

Research use only, not for human use.

Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.

Diloxanide furoate is the proagent of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.

Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica, it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively.

Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats.Animal Model:Weanling Wistar rats Dosage:200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg Administration:Oral administraion; 75-200 mg/kg; 3 days; once daily Result:Was against intestinal (caecal) amoebiasis in rats.

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Microbiology/Virology

Parasite

Parasite

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3736-81-0

328.15

C14H11Cl2NO4

>98% (HPLC)

In Vitro:?DMSO : ≥ 50 mg/mL (152.37 mM )

O=C(OC1=CC=C(C=C1)N(C(=O)C(Cl)Cl)C)C=2OC=CC2

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(-20℃)

With Ice Pack

≥ 2 years